Prognostic Significance of Metallothionein, p53 Protein and Ki-67 Antigen Expression in Laryngeal Cancer
Background: This study aimed at the evaluation of the expression of metallothionein (MT) in laryngeal carcinoma and its correlation with the expression of Ki-67 antigen and p53 protein and selected clinical and pathological variables in view of their potential prognostic significance. Materials and...
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| Veröffentlicht in: | Anticancer research 2007-01, Vol.27 (1A), p.335-342 |
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| creator | PASTUSZEWSKI, Wojciech DZIEGIEL, Piotr KRECICKI, Tomasz PODHORSKA-OKOLOW, Marzena CIESIELSKA, Urszula GORZYNSKA, Elzbieta ZABEL, Maciej |
| description | Background: This study aimed at the evaluation of the expression of metallothionein (MT) in laryngeal carcinoma and its correlation
with the expression of Ki-67 antigen and p53 protein and selected clinical and pathological variables in view of their potential
prognostic significance. Materials and Methods: Sixty-five laryngeal cancer patients were retrospectively analysed. Expression
of MT, Ki-67 and p53 in tumour tissue samples were assessed by immunohistochemistry. Results: In laryngeal cancer a significantly
augmented expression of MT, Ki-67 and p53 was noted, as compared to the control group (p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70251723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20287709</sourcerecordid><originalsourceid>FETCH-LOGICAL-h300t-b1a03ce585c00b0e121f13929afd90b6be417ec9de647141cbc7a55b3b06da323</originalsourceid><addsrcrecordid>eNqF0E1LxDAQBuAiiruu_gXJRU8WJsmmaY_Lsn7gioJ6Dmk6bSNtuiZd1H9vxBW9eRqGeXhh3r1kSmVBUyk47CdTYAJSCSAmyVEILwBZVuT8MJlQyQVjgk6T9sEPjRvCaA15tI2ztTXaGSRDTe5w1F03jK0dHFp3QTaCk-jHuBDtKnJr00yShRttg46s3jceQ4iYxPta-w_XoO7I8ivPHycHte4CnuzmLHm-XD0tr9P1_dXNcrFOWw4wpiXVwA2KXBiAEpAyWlNesELXVQFlVuKcSjRFhdlc0jk1pZFaiJKXkFWaMz5Lzr9zN3543WIYVW-Dwa7TDodtUDKWQiXj_0IGLJcSighPd3Bb9lipjbd9fE79lBjB2Q7oYHRX-_iwDb8uFxnjxR_X2qZ9sx5V6GPBMZYr7ZlUdKE4F_wTj_mHzg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20287709</pqid></control><display><type>article</type><title>Prognostic Significance of Metallothionein, p53 Protein and Ki-67 Antigen Expression in Laryngeal Cancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>PASTUSZEWSKI, Wojciech ; DZIEGIEL, Piotr ; KRECICKI, Tomasz ; PODHORSKA-OKOLOW, Marzena ; CIESIELSKA, Urszula ; GORZYNSKA, Elzbieta ; ZABEL, Maciej</creator><creatorcontrib>PASTUSZEWSKI, Wojciech ; DZIEGIEL, Piotr ; KRECICKI, Tomasz ; PODHORSKA-OKOLOW, Marzena ; CIESIELSKA, Urszula ; GORZYNSKA, Elzbieta ; ZABEL, Maciej</creatorcontrib><description>Background: This study aimed at the evaluation of the expression of metallothionein (MT) in laryngeal carcinoma and its correlation
with the expression of Ki-67 antigen and p53 protein and selected clinical and pathological variables in view of their potential
prognostic significance. Materials and Methods: Sixty-five laryngeal cancer patients were retrospectively analysed. Expression
of MT, Ki-67 and p53 in tumour tissue samples were assessed by immunohistochemistry. Results: In laryngeal cancer a significantly
augmented expression of MT, Ki-67 and p53 was noted, as compared to the control group (p<0.001) and a significantly increased
expression of MT in low malignancy tumours (G1) as compared to the control group (p<0.001). The expression of Ki-67 antigen
was positively correlated with the expression of p53 protein (r=0.477; p<0.05) and expression of either marker was positively
correlated with malignancy grade (r=0.47, p<0.05; r=0.31, p<0.05; for Ki-67 and p53, respectively). Shortened survival was
noted in patients with high expression of Ki-67 antigen and p53 protein. Conclusion: The intensity of MT expression was not
related to prognosis in laryngeal cancer. Nevertheless, it may provide a significant index indicating the malignant transformation
of benign lesions of laryngeal epithelium.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 17352251</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cell Nucleus - metabolism ; Cytoplasm - metabolism ; Female ; Humans ; Ki-67 Antigen - biosynthesis ; Laryngeal Neoplasms - metabolism ; Laryngeal Neoplasms - pathology ; Male ; Medical sciences ; Metallothionein - biosynthesis ; Middle Aged ; Otorhinolaryngology. Stomatology ; Prognosis ; Survival Analysis ; Tumor Suppressor Protein p53 - biosynthesis ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Anticancer research, 2007-01, Vol.27 (1A), p.335-342</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18562391$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17352251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PASTUSZEWSKI, Wojciech</creatorcontrib><creatorcontrib>DZIEGIEL, Piotr</creatorcontrib><creatorcontrib>KRECICKI, Tomasz</creatorcontrib><creatorcontrib>PODHORSKA-OKOLOW, Marzena</creatorcontrib><creatorcontrib>CIESIELSKA, Urszula</creatorcontrib><creatorcontrib>GORZYNSKA, Elzbieta</creatorcontrib><creatorcontrib>ZABEL, Maciej</creatorcontrib><title>Prognostic Significance of Metallothionein, p53 Protein and Ki-67 Antigen Expression in Laryngeal Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: This study aimed at the evaluation of the expression of metallothionein (MT) in laryngeal carcinoma and its correlation
with the expression of Ki-67 antigen and p53 protein and selected clinical and pathological variables in view of their potential
prognostic significance. Materials and Methods: Sixty-five laryngeal cancer patients were retrospectively analysed. Expression
of MT, Ki-67 and p53 in tumour tissue samples were assessed by immunohistochemistry. Results: In laryngeal cancer a significantly
augmented expression of MT, Ki-67 and p53 was noted, as compared to the control group (p<0.001) and a significantly increased
expression of MT in low malignancy tumours (G1) as compared to the control group (p<0.001). The expression of Ki-67 antigen
was positively correlated with the expression of p53 protein (r=0.477; p<0.05) and expression of either marker was positively
correlated with malignancy grade (r=0.47, p<0.05; r=0.31, p<0.05; for Ki-67 and p53, respectively). Shortened survival was
noted in patients with high expression of Ki-67 antigen and p53 protein. Conclusion: The intensity of MT expression was not
related to prognosis in laryngeal cancer. Nevertheless, it may provide a significant index indicating the malignant transformation
of benign lesions of laryngeal epithelium.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cell Nucleus - metabolism</subject><subject>Cytoplasm - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Ki-67 Antigen - biosynthesis</subject><subject>Laryngeal Neoplasms - metabolism</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metallothionein - biosynthesis</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LxDAQBuAiiruu_gXJRU8WJsmmaY_Lsn7gioJ6Dmk6bSNtuiZd1H9vxBW9eRqGeXhh3r1kSmVBUyk47CdTYAJSCSAmyVEILwBZVuT8MJlQyQVjgk6T9sEPjRvCaA15tI2ztTXaGSRDTe5w1F03jK0dHFp3QTaCk-jHuBDtKnJr00yShRttg46s3jceQ4iYxPta-w_XoO7I8ivPHycHte4CnuzmLHm-XD0tr9P1_dXNcrFOWw4wpiXVwA2KXBiAEpAyWlNesELXVQFlVuKcSjRFhdlc0jk1pZFaiJKXkFWaMz5Lzr9zN3543WIYVW-Dwa7TDodtUDKWQiXj_0IGLJcSighPd3Bb9lipjbd9fE79lBjB2Q7oYHRX-_iwDb8uFxnjxR_X2qZ9sx5V6GPBMZYr7ZlUdKE4F_wTj_mHzg</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>PASTUSZEWSKI, Wojciech</creator><creator>DZIEGIEL, Piotr</creator><creator>KRECICKI, Tomasz</creator><creator>PODHORSKA-OKOLOW, Marzena</creator><creator>CIESIELSKA, Urszula</creator><creator>GORZYNSKA, Elzbieta</creator><creator>ZABEL, Maciej</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Prognostic Significance of Metallothionein, p53 Protein and Ki-67 Antigen Expression in Laryngeal Cancer</title><author>PASTUSZEWSKI, Wojciech ; DZIEGIEL, Piotr ; KRECICKI, Tomasz ; PODHORSKA-OKOLOW, Marzena ; CIESIELSKA, Urszula ; GORZYNSKA, Elzbieta ; ZABEL, Maciej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h300t-b1a03ce585c00b0e121f13929afd90b6be417ec9de647141cbc7a55b3b06da323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cell Nucleus - metabolism</topic><topic>Cytoplasm - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Ki-67 Antigen - biosynthesis</topic><topic>Laryngeal Neoplasms - metabolism</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metallothionein - biosynthesis</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>Survival Analysis</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PASTUSZEWSKI, Wojciech</creatorcontrib><creatorcontrib>DZIEGIEL, Piotr</creatorcontrib><creatorcontrib>KRECICKI, Tomasz</creatorcontrib><creatorcontrib>PODHORSKA-OKOLOW, Marzena</creatorcontrib><creatorcontrib>CIESIELSKA, Urszula</creatorcontrib><creatorcontrib>GORZYNSKA, Elzbieta</creatorcontrib><creatorcontrib>ZABEL, Maciej</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PASTUSZEWSKI, Wojciech</au><au>DZIEGIEL, Piotr</au><au>KRECICKI, Tomasz</au><au>PODHORSKA-OKOLOW, Marzena</au><au>CIESIELSKA, Urszula</au><au>GORZYNSKA, Elzbieta</au><au>ZABEL, Maciej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of Metallothionein, p53 Protein and Ki-67 Antigen Expression in Laryngeal Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>27</volume><issue>1A</issue><spage>335</spage><epage>342</epage><pages>335-342</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: This study aimed at the evaluation of the expression of metallothionein (MT) in laryngeal carcinoma and its correlation
with the expression of Ki-67 antigen and p53 protein and selected clinical and pathological variables in view of their potential
prognostic significance. Materials and Methods: Sixty-five laryngeal cancer patients were retrospectively analysed. Expression
of MT, Ki-67 and p53 in tumour tissue samples were assessed by immunohistochemistry. Results: In laryngeal cancer a significantly
augmented expression of MT, Ki-67 and p53 was noted, as compared to the control group (p<0.001) and a significantly increased
expression of MT in low malignancy tumours (G1) as compared to the control group (p<0.001). The expression of Ki-67 antigen
was positively correlated with the expression of p53 protein (r=0.477; p<0.05) and expression of either marker was positively
correlated with malignancy grade (r=0.47, p<0.05; r=0.31, p<0.05; for Ki-67 and p53, respectively). Shortened survival was
noted in patients with high expression of Ki-67 antigen and p53 protein. Conclusion: The intensity of MT expression was not
related to prognosis in laryngeal cancer. Nevertheless, it may provide a significant index indicating the malignant transformation
of benign lesions of laryngeal epithelium.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17352251</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Cell Nucleus - metabolism Cytoplasm - metabolism Female Humans Ki-67 Antigen - biosynthesis Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Male Medical sciences Metallothionein - biosynthesis Middle Aged Otorhinolaryngology. Stomatology Prognosis Survival Analysis Tumor Suppressor Protein p53 - biosynthesis Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Prognostic Significance of Metallothionein, p53 Protein and Ki-67 Antigen Expression in Laryngeal Cancer |
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