Prognostic Significance of Metallothionein, p53 Protein and Ki-67 Antigen Expression in Laryngeal Cancer

Background: This study aimed at the evaluation of the expression of metallothionein (MT) in laryngeal carcinoma and its correlation with the expression of Ki-67 antigen and p53 protein and selected clinical and pathological variables in view of their potential prognostic significance. Materials and...

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Veröffentlicht in:	Anticancer research 2007-01, Vol.27 (1A), p.335-342
Hauptverfasser:	PASTUSZEWSKI, Wojciech, DZIEGIEL, Piotr, KRECICKI, Tomasz, PODHORSKA-OKOLOW, Marzena, CIESIELSKA, Urszula, GORZYNSKA, Elzbieta, ZABEL, Maciej
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Cell Nucleus - metabolism Cytoplasm - metabolism Female Humans Ki-67 Antigen - biosynthesis Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Male Medical sciences Metallothionein - biosynthesis Middle Aged Otorhinolaryngology. Stomatology Prognosis Survival Analysis Tumor Suppressor Protein p53 - biosynthesis Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Zusammenfassung:	Background: This study aimed at the evaluation of the expression of metallothionein (MT) in laryngeal carcinoma and its correlation with the expression of Ki-67 antigen and p53 protein and selected clinical and pathological variables in view of their potential prognostic significance. Materials and Methods: Sixty-five laryngeal cancer patients were retrospectively analysed. Expression of MT, Ki-67 and p53 in tumour tissue samples were assessed by immunohistochemistry. Results: In laryngeal cancer a significantly augmented expression of MT, Ki-67 and p53 was noted, as compared to the control group (p
ISSN:	0250-7005 1791-7530