IMMUNOGENICITY AND SAFETY OF A PENTAVALENT HUMAN-BOVINE (WC3) REASSORTANT ROTAVIRUS VACCINE IN HEALTHY INFANTS IN KOREA

We evaluated the immunogenicity and safety of pentavalent human-bovine reassortant rotavirus vaccine in 178 Korean healthy infants. Seroresponse rate for serum antirotavirus IgA titers was 94.7% among 94 vaccine recipients, as compared with 13.5% among 52 placebo recipients. Seroresponse rates in se...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Pediatric infectious disease journal 2008-02, Vol.27 (2), p.177-178
Hauptverfasser:	Kim, Dong Soo, Lee, Taek Jin, Kang, Jin Han, Kim, Jong-Hyun, Lee, Jung Hyun, Ma, Sang Hyuk, Kim, Sun Young, Kim, Hwang Min, Shin, Son Mun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood Biological and medical sciences Cattle Double-Blind Method Human viral diseases Humans Infant Infectious diseases Korea Medical sciences Reassortant Viruses - immunology Rotavirus - immunology Rotavirus Vaccines - adverse effects Rotavirus Vaccines - immunology Viral diseases Viral diseases of the digestive system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We evaluated the immunogenicity and safety of pentavalent human-bovine reassortant rotavirus vaccine in 178 Korean healthy infants. Seroresponse rate for serum antirotavirus IgA titers was 94.7% among 94 vaccine recipients, as compared with 13.5% among 52 placebo recipients. Seroresponse rates in serum neutralizing antibody to each human rotavirus serotype in the vaccine were significantly higher in the vaccine group than in the placebo group. This vaccine was generally well tolerated and immunogenic.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0b013e31815aba79