Synthesis and primary cytotoxicity evaluation of new imidazo[2,1- b]thiazole derivatives

A series of arylidenehydrazides ( 3a– 3i) were synthesized from [6-(4-bromophenyl)imidazo[2,1- b]thiazol-3-yl]acetic acid hydrazide. The structures of new compounds were determined by analytical and spectral (IR, 1H NMR, 13C NMR, EIMS) methods. The synthesized compounds ( 3a– 3i) were evaluated in the National Cancer Institute's 3-cell line, one dose in vitro primary cytotoxicity assay. Compounds 3a– 3c, 3h and 3i which passed the criteria for activity in this assay were scheduled automatically for evaluation against the full panel of 60 human tumour cell lines at a minimum of five concentrations at 10-fold dilutions. Compounds 3c demonstrated the most marked effects on a prostate cancer cell line (PC-3, log 10 GI 50 value < −8.00). [Display omitted]