Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates

Structure-based design of alkyl sugar-1-phosphates provides an efficient nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides possessing long or branched alkyl chains, thereby demonstrating the utility of nucleotidylyltransferases to catalyze the synthesis of...

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Veröffentlicht in:	Organic & biomolecular chemistry 2008-02, Vol.6 (3), p.477-484
Hauptverfasser:	Huestis, Malcolm P, Aish, Gaia A, Hui, Joseph P M, Soo, Evelyn C, Jakeman, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Crystallography, X-Ray Glucose - analogs & derivatives Glucose - chemistry Glucose - metabolism Models, Molecular Nucleotides - chemical synthesis Nucleotidyltransferases - chemistry Nucleotidyltransferases - metabolism Protein Structure, Secondary Pseudomonas aeruginosa - enzymology Rhamnose - analogs & derivatives Rhamnose - chemistry Rhamnose - metabolism Substrate Specificity Sugar Phosphates Thymine Nucleotides - chemistry Thymine Nucleotides - metabolism
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Beschreibung
Zusammenfassung:	Structure-based design of alkyl sugar-1-phosphates provides an efficient nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides possessing long or branched alkyl chains, thereby demonstrating the utility of nucleotidylyltransferases to catalyze the synthesis of sugar nucleotides with potential applications in lipopolysaccharide and lipoglycopeptide biosynthesis.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/b716955h