Effect of Homocysteine Concentration in Early Pregnancy on Gestational Hypertensive Disorders and Other Pregnancy Outcomes

Increased total homocysteine (tHcy) may be associated with placental-mediated adverse pregnancy outcomes, but few prospective studies have measured tHcy before pregnancy outcome. This study was undertaken to determine whether increased tHcy measured in early pregnancy is associated with pregnancy lo...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2008-02, Vol.54 (2), p.326-334
Hauptverfasser:	Dodds, Linda, Fell, Deshayne B, Dooley, Kent C, Armson, B. Anthony, Allen, Alexander C, Nassar, Bassam A, Perkins, Sherry, Joseph, K.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Spontaneous - epidemiology Analytical, structural and metabolic biochemistry Biological and medical sciences Birth weight Chemical compounds Female Fundamental and applied biological sciences. Psychology Homocysteine - blood Humans Hypertension Hypertension, Pregnancy-Induced - epidemiology Infant, Newborn Infant, Small for Gestational Age Infants Investigative techniques, diagnostic techniques (general aspects) Medical research Medical sciences Pre-Eclampsia - epidemiology Pregnancy Risk Factors Womens health
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Zusammenfassung:	Increased total homocysteine (tHcy) may be associated with placental-mediated adverse pregnancy outcomes, but few prospective studies have measured tHcy before pregnancy outcome. This study was undertaken to determine whether increased tHcy measured in early pregnancy is associated with pregnancy loss, gestational hypertension (GH), preeclampsia, or small for gestational age (SGA) infants. We conducted a prospective cohort study between 2002 and 2005. We measured tHcy and serum folate in blood samples from pregnant women (
ISSN:	0009-9147 1530-8561
DOI:	10.1373/clinchem.2007.097469