All-Carbon Quaternary Stereogenic Centers by Enantioselective Cu-Catalyzed Conjugate Additions Promoted by a Chiral N-Heterocyclic Carbene
Necessity is the mother of invention: When the available catalysts do not cut it, a new one has to be developed. A chiral N‐heterocyclic carbene (NHC) is used in the first catalytic asymmetric conjugate addition of alkyl‐ and arylzinc reagents to γ‐keto esters (see scheme).
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| Veröffentlicht in: | Angewandte Chemie International Edition 2007-01, Vol.46 (7), p.1097-1100 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Brown, M. Kevin May, Tricia L. Baxter, Carl A. Hoveyda, Amir H. |
| description | Necessity is the mother of invention: When the available catalysts do not cut it, a new one has to be developed. A chiral N‐heterocyclic carbene (NHC) is used in the first catalytic asymmetric conjugate addition of alkyl‐ and arylzinc reagents to γ‐keto esters (see scheme). |
| doi_str_mv | 10.1002/anie.200604511 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2007-01, Vol.46 (7), p.1097-1100 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | asymmetric catalysis asymmetric synthesis carbenes Carbon - pharmacology Catalysis conjugate addition Copper - chemistry Crystallography, X-Ray Hydrocarbons - chemistry Methane - analogs & derivatives Methane - chemistry Organometallic Compounds - chemistry quaternary centers Stereoisomerism |
| title | All-Carbon Quaternary Stereogenic Centers by Enantioselective Cu-Catalyzed Conjugate Additions Promoted by a Chiral N-Heterocyclic Carbene |
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