All-Carbon Quaternary Stereogenic Centers by Enantioselective Cu-Catalyzed Conjugate Additions Promoted by a Chiral N-Heterocyclic Carbene

All-Carbon Quaternary Stereogenic Centers by Enantioselective Cu-Catalyzed Conjugate Additions Promoted by a Chiral N-Heterocyclic Carbene

Necessity is the mother of invention: When the available catalysts do not cut it, a new one has to be developed. A chiral N‐heterocyclic carbene (NHC) is used in the first catalytic asymmetric conjugate addition of alkyl‐ and arylzinc reagents to γ‐keto esters (see scheme).

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2007-01, Vol.46 (7), p.1097-1100
Hauptverfasser: Brown, M. Kevin, May, Tricia L., Baxter, Carl A., Hoveyda, Amir H.
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
asymmetric synthesis
carbenes
Carbon - pharmacology
Catalysis
conjugate addition
Copper - chemistry
Crystallography, X-Ray
Hydrocarbons - chemistry
Methane - analogs & derivatives
Methane - chemistry
Organometallic Compounds - chemistry
quaternary centers
Stereoisomerism
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Beschreibung
Zusammenfassung:Necessity is the mother of invention: When the available catalysts do not cut it, a new one has to be developed. A chiral N‐heterocyclic carbene (NHC) is used in the first catalytic asymmetric conjugate addition of alkyl‐ and arylzinc reagents to γ‐keto esters (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200604511