Comparative Study of the Usefulness of the Drug-Induced Lymphocyte Stimulation Test and the Leukocyte Migration Test in Drug Allergies

In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identif...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2008/02/01, Vol.31(2), pp.299-304
Hauptverfasser:	Saito, Mikio, Yagi, Motohiro, Uno, Katsuji, Takanaka, Koichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult age and sex Aged Aged, 80 and over Aging - physiology Antibody Specificity Antigens - chemistry Antigens - isolation & purification causative drug Cell Migration Assays, Leukocyte Cell Separation Child Child, Preschool drug allergy Drug Hypersensitivity - diagnosis drug-induced lymphocyte stimulation test Female Humans hypersensitivity symptom Infant leukocyte migration test Lymphocyte Activation - drug effects Male Middle Aged Monocytes - drug effects Predictive Value of Tests Sex Characteristics
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Zusammenfassung:	In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test (DLST) and the leukocyte migration test (LMT) to compare their usefulness in identifying drug allergies. In the 133 subject patients, the positive rate was 24.8% on the DLST and 60.9% on the LMT (agreement rate; 77.4%); thus, the LMT showed a significantly higher positive rate than the DLST (p
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.31.299