Synthesis and antimicrobial activity of 1-(4-aryl-2-thiazolyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives

Several 1-(4-aryl-2-thiazolyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting substituted 3-(2-thienyl)-5-aryl-1-thiocarbamoyl-2-pyrazolines with phenacyl bromides in ethanol. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, and EIMS spectral...

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Veröffentlicht in:	European journal of medicinal chemistry 2007-03, Vol.42 (3), p.403-409
Hauptverfasser:	Özdemir, Ahmet, Turan-Zitouni, Gülhan, Asım Kaplancıklı, Zafer, Revial, Gilbert, Güven, Kıymet
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyrazoline Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Antimicrobial activity Bacteria - drug effects Biological and medical sciences Fungi - drug effects General aspects Indicators and Reagents Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Molecular Conformation Pharmacology. Drug treatments Pyrazoles - chemical synthesis Pyrazoles - pharmacology Spectrometry, Mass, Electrospray Ionization Thiazole Thiazoles - chemical synthesis Thiazoles - pharmacology
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Zusammenfassung:	Several 1-(4-aryl-2-thiazolyl)-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by reacting substituted 3-(2-thienyl)-5-aryl-1-thiocarbamoyl-2-pyrazolines with phenacyl bromides in ethanol. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, and EIMS spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3704), Staphylococcus aureus (NRLL B-767), Salmonella typhimurium (NRRL B-4420), Bacillus cereus (NRRL B-3711), Streptococcus faecalis (NRRL B-14617), Aeromonas hydrophila (Ankara Uni. Fac. of Veterinary), Candida albicans and Candida glabrata (isolates obtained from Osmangazi Uni. Fac. of Medicine) were investigated. A significant level of activity was observed. [Display omitted]
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2006.10.001