Special Delivery: Dynamic Targeting via Cortical Capture of Microtubules

Gap junction formation depends on the proper transport of connexin hemichannels to sites of cell-cell contact. Recently in Cell, Shaw et al. implicate microtubule tip tracking proteins in the trafficking of connexin43 to adherens junctions ( Shaw et al., 2007). This finding suggests a mechanism for...

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Veröffentlicht in:Developmental cell 2007-03, Vol.12 (3), p.320-322
Hauptverfasser: Levy, Jennifer R., Holzbaur, Erika L.F.
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Holzbaur, Erika L.F.
description Gap junction formation depends on the proper transport of connexin hemichannels to sites of cell-cell contact. Recently in Cell, Shaw et al. implicate microtubule tip tracking proteins in the trafficking of connexin43 to adherens junctions ( Shaw et al., 2007). This finding suggests a mechanism for targeted delivery of membrane proteins by microtubule capture at the cortex.
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subjects Adherens Junctions - metabolism
Adherens Junctions - ultrastructure
Animals
Biological and medical sciences
Cell Adhesion Molecules - metabolism
Cell Communication - physiology
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Cell structures and functions
Connexins - metabolism
Cytoskeleton, cytoplasm. Intracellular movements
Fundamental and applied biological sciences. Psychology
Gap Junctions - metabolism
Gap Junctions - ultrastructure
Humans
Intercellular Junctions - metabolism
Intercellular Junctions - ultrastructure
Microtubules - metabolism
Microtubules - ultrastructure
Molecular and cellular biology
Molecular Motor Proteins - metabolism
Protein Transport - physiology
title Special Delivery: Dynamic Targeting via Cortical Capture of Microtubules
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