Special Delivery: Dynamic Targeting via Cortical Capture of Microtubules

Gap junction formation depends on the proper transport of connexin hemichannels to sites of cell-cell contact. Recently in Cell, Shaw et al. implicate microtubule tip tracking proteins in the trafficking of connexin43 to adherens junctions ( Shaw et al., 2007). This finding suggests a mechanism for...

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Veröffentlicht in:	Developmental cell 2007-03, Vol.12 (3), p.320-322
Hauptverfasser:	Levy, Jennifer R., Holzbaur, Erika L.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens Junctions - metabolism Adherens Junctions - ultrastructure Animals Biological and medical sciences Cell Adhesion Molecules - metabolism Cell Communication - physiology Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell structures and functions Connexins - metabolism Cytoskeleton, cytoplasm. Intracellular movements Fundamental and applied biological sciences. Psychology Gap Junctions - metabolism Gap Junctions - ultrastructure Humans Intercellular Junctions - metabolism Intercellular Junctions - ultrastructure Microtubules - metabolism Microtubules - ultrastructure Molecular and cellular biology Molecular Motor Proteins - metabolism Protein Transport - physiology
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Beschreibung
Zusammenfassung:	Gap junction formation depends on the proper transport of connexin hemichannels to sites of cell-cell contact. Recently in Cell, Shaw et al. implicate microtubule tip tracking proteins in the trafficking of connexin43 to adherens junctions ( Shaw et al., 2007). This finding suggests a mechanism for targeted delivery of membrane proteins by microtubule capture at the cortex.
ISSN:	1534-5807 1878-1551
DOI:	10.1016/j.devcel.2007.02.012