Highly Enantioselective Water-Compatible Organocatalyst for Michael Reaction of Ketones to Nitroolefins
A chiral diamine was found to catalyze enantioselective addition of ketones to nitroolefins in aqueous/saline/organic media. The products were obtained with excellent diastereoselectivities (syn/anti = 99:1) and enantioselectivities up to 99%. The reaction could be facilitated using a mild acid.
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| Veröffentlicht in: | Organic letters 2007-03, Vol.9 (6), p.1117-1119 |
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| container_title | Organic letters |
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| creator | Vishnumaya Singh, Vinod K |
| description | A chiral diamine was found to catalyze enantioselective addition of ketones to nitroolefins in aqueous/saline/organic media. The products were obtained with excellent diastereoselectivities (syn/anti = 99:1) and enantioselectivities up to 99%. The reaction could be facilitated using a mild acid. |
| doi_str_mv | 10.1021/ol070082x |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2007-03, Vol.9 (6), p.1117-1119 |
| issn | 1523-7060 1523-7052 |
| language | eng |
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| source | ACS Publications |
| title | Highly Enantioselective Water-Compatible Organocatalyst for Michael Reaction of Ketones to Nitroolefins |
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