Highly Enantioselective Water-Compatible Organocatalyst for Michael Reaction of Ketones to Nitroolefins
A chiral diamine was found to catalyze enantioselective addition of ketones to nitroolefins in aqueous/saline/organic media. The products were obtained with excellent diastereoselectivities (syn/anti = 99:1) and enantioselectivities up to 99%. The reaction could be facilitated using a mild acid.
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| Veröffentlicht in: | Organic letters 2007-03, Vol.9 (6), p.1117-1119 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A chiral diamine was found to catalyze enantioselective addition of ketones to nitroolefins in aqueous/saline/organic media. The products were obtained with excellent diastereoselectivities (syn/anti = 99:1) and enantioselectivities up to 99%. The reaction could be facilitated using a mild acid. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/ol070082x |