Sertoli-Leydig cell tumours of the ovary and testis : a CGH and FISH study

We present two malignant cases of Sertoli-Leydig cell tumours (SLCT) of the testis and one ovarian SLCT with benign behaviour. The DNA copy number changes affected chromosome 1, 8, 9p, 10, 11, 12, 16, 19, 22 and X. The present study is the first molecular-cytogenetic analysis of Sertoli-Leydig cell...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2007-03, Vol.450 (3), p.267-271
Hauptverfasser:	VERDORFER, I, HORST, D, HÖLLRIGL, A, ROGATSCH, H, MIKUZ, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Chromosome Aberrations Female Gene Dosage Gynecology. Andrology. Obstetrics Humans In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Karyotyping Male Male genital diseases Medical sciences Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Sertoli-Leydig Cell Tumor - genetics Sertoli-Leydig Cell Tumor - metabolism Sertoli-Leydig Cell Tumor - pathology Testicular Neoplasms - genetics Testicular Neoplasms - metabolism Testicular Neoplasms - pathology Tumors
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Zusammenfassung:	We present two malignant cases of Sertoli-Leydig cell tumours (SLCT) of the testis and one ovarian SLCT with benign behaviour. The DNA copy number changes affected chromosome 1, 8, 9p, 10, 11, 12, 16, 19, 22 and X. The present study is the first molecular-cytogenetic analysis of Sertoli-Leydig cell tumours of the testis.
ISSN:	0945-6317 1432-2307
DOI:	10.1007/s00428-006-0344-9