Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone

On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3beta (GSK3beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/beta-catenin signaling pathway...

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Veröffentlicht in:	Journal of proteome research 2007-03, Vol.6 (3), p.1198-1208
Hauptverfasser:	Maurer, Martin H, Brömme, Jens O, Feldmann, Jr, Robert E, Järve, Anne, Sabouri, Fatemeh, Bürgers, Heinrich F, Schelshorn, Dominik W, Krüger, Carola, Schneider, Armin, Kuschinsky, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis beta Catenin - genetics beta Catenin - metabolism Cell Differentiation Cell Proliferation Cerebral Ventricles - cytology Electrophoresis, Gel, Two-Dimensional Glycogen Synthase Kinase 3 - physiology Glycogen Synthase Kinase 3 beta Neurons - cytology Neurons - enzymology Proteomics - methods Rats Stem Cells - cytology Stem Cells - enzymology Wnt Proteins - metabolism
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Zusammenfassung:	On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3beta (GSK3beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/beta-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of beta-catenin target genes during GSK3beta inhibition, associated with decreased apoptosis.
ISSN:	1535-3893