CD117 Immunoreactivity in Atypical Fibroxanthoma
Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly. Though described as a benign entity, local recurrence and distant metastasis have been reported. This study aims to investigate the potential pathogenic role of CD117, the c-kit rec...
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| Veröffentlicht in: | The American journal of dermatopathology 2008-02, Vol.30 (1), p.34-36 |
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| container_title | The American journal of dermatopathology |
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| creator | MATHEW, Rahel A SCHLAUDER, Scott M COLDER, Kenneth B MORGAN, Michael B |
| description | Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly. Though described as a benign entity, local recurrence and distant metastasis have been reported. This study aims to investigate the potential pathogenic role of CD117, the c-kit receptor in AFX. CD117 was detected in 15 of the 16 cases (94%). The percentage of positive cells for CD117 expression among all tumors was approximately 30%. CD117 proved to be a very sensitive marker of AFX. This antibody may be a useful diagnostic adjunct in AFX. |
| doi_str_mv | 10.1097/DAD.0b013e31815b8ed5 |
| format | Article |
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| identifier | ISSN: 0193-1091 |
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| issn | 0193-1091 1533-0311 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - analysis Dermatology Histiocytoma, Benign Fibrous - metabolism Histiocytoma, Benign Fibrous - pathology Humans Immunohistochemistry Male Medical sciences Proto-Oncogene Proteins c-kit - biosynthesis Skin Neoplasms - metabolism Skin Neoplasms - pathology |
| title | CD117 Immunoreactivity in Atypical Fibroxanthoma |
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