CD117 Immunoreactivity in Atypical Fibroxanthoma

Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly. Though described as a benign entity, local recurrence and distant metastasis have been reported. This study aims to investigate the potential pathogenic role of CD117, the c-kit rec...

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Veröffentlicht in:	The American journal of dermatopathology 2008-02, Vol.30 (1), p.34-36
Hauptverfasser:	MATHEW, Rahel A, SCHLAUDER, Scott M, COLDER, Kenneth B, MORGAN, Michael B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - analysis Dermatology Histiocytoma, Benign Fibrous - metabolism Histiocytoma, Benign Fibrous - pathology Humans Immunohistochemistry Male Medical sciences Proto-Oncogene Proteins c-kit - biosynthesis Skin Neoplasms - metabolism Skin Neoplasms - pathology
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Zusammenfassung:	Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly. Though described as a benign entity, local recurrence and distant metastasis have been reported. This study aims to investigate the potential pathogenic role of CD117, the c-kit receptor in AFX. CD117 was detected in 15 of the 16 cases (94%). The percentage of positive cells for CD117 expression among all tumors was approximately 30%. CD117 proved to be a very sensitive marker of AFX. This antibody may be a useful diagnostic adjunct in AFX.
ISSN:	0193-1091 1533-0311
DOI:	10.1097/DAD.0b013e31815b8ed5