Modular design for in vivo optical imaging and ultrasound treatment in the murine brain
Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric constraints. We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope...
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| Veröffentlicht in: | IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2007-02, Vol.54 (2), p.431-434 |
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| container_title | IEEE transactions on ultrasonics, ferroelectrics, and frequency control |
| container_volume | 54 |
| creator | Raymond, S.B. Skoch, J. Bacskai, B.J. Hynynen, K. |
| description | Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric constraints. We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope, and animals are imaged during ultrasound-induced blood-brain barrier disruption |
| doi_str_mv | 10.1109/TUFFC.2007.257 |
| format | Article |
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We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope, and animals are imaged during ultrasound-induced blood-brain barrier disruption</description><identifier>ISSN: 0885-3010</identifier><identifier>EISSN: 1525-8955</identifier><identifier>DOI: 10.1109/TUFFC.2007.257</identifier><identifier>PMID: 17328340</identifier><identifier>CODEN: ITUCER</identifier><language>eng</language><publisher>New York, NY: IEEE</publisher><subject>Acoustic transducers ; Acoustics ; Animals ; Biological and medical sciences ; Biomedical materials ; Blood-brain barrier ; Blood-Brain Barrier - cytology ; Blood-Brain Barrier - radiation effects ; Brain ; Brain - cytology ; Brain - radiation effects ; Equipment Design ; Equipment Failure Analysis ; Exact sciences and technology ; Focusing ; Fundamental areas of phenomenology (including applications) ; General equipment and techniques ; Geometric constraints ; Imaging ; In vivo ; In vivo testing ; In vivo tests ; Instruments, apparatus, components and techniques common to several branches of physics and astronomy ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Microscopy ; Microscopy, Fluorescence, Multiphoton - instrumentation ; Microscopy, Fluorescence, Multiphoton - methods ; Microscopy, Fluorescence, Multiphoton - veterinary ; Miscellaneous. Technology ; Optical design ; Optical imaging ; Physics ; Skull ; Sonication - instrumentation ; Systems Integration ; Transducers ; Ultrasonic imaging ; Ultrasonic investigative techniques ; Ultrasonic Therapy - instrumentation ; Ultrasonic Therapy - methods ; Ultrasonic Therapy - veterinary ; Ultrasonic transducers ; Ultrasonics, quantum acoustics, and physical effects of sound ; Ultrasound</subject><ispartof>IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2007-02, Vol.54 (2), p.431-434</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-20f80af433cfbaa949411a3659e6a5c0422812bb635469d75e2d814940a698ef3</citedby><cites>FETCH-LOGICAL-c464t-20f80af433cfbaa949411a3659e6a5c0422812bb635469d75e2d814940a698ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/4107702$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,776,780,792,27901,27902,54733</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/4107702$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18490809$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17328340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raymond, S.B.</creatorcontrib><creatorcontrib>Skoch, J.</creatorcontrib><creatorcontrib>Bacskai, B.J.</creatorcontrib><creatorcontrib>Hynynen, K.</creatorcontrib><title>Modular design for in vivo optical imaging and ultrasound treatment in the murine brain</title><title>IEEE transactions on ultrasonics, ferroelectrics, and frequency control</title><addtitle>T-UFFC</addtitle><addtitle>IEEE Trans Ultrason Ferroelectr Freq Control</addtitle><description>Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric constraints. We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope, and animals are imaged during ultrasound-induced blood-brain barrier disruption</description><subject>Acoustic transducers</subject><subject>Acoustics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical materials</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - cytology</subject><subject>Blood-Brain Barrier - radiation effects</subject><subject>Brain</subject><subject>Brain - cytology</subject><subject>Brain - radiation effects</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Exact sciences and technology</subject><subject>Focusing</subject><subject>Fundamental areas of phenomenology (including applications)</subject><subject>General equipment and techniques</subject><subject>Geometric constraints</subject><subject>Imaging</subject><subject>In vivo</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>Instruments, apparatus, components and techniques common to several branches of physics and astronomy</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microscopy</subject><subject>Microscopy, Fluorescence, Multiphoton - instrumentation</subject><subject>Microscopy, Fluorescence, Multiphoton - methods</subject><subject>Microscopy, Fluorescence, Multiphoton - veterinary</subject><subject>Miscellaneous. Technology</subject><subject>Optical design</subject><subject>Optical imaging</subject><subject>Physics</subject><subject>Skull</subject><subject>Sonication - instrumentation</subject><subject>Systems Integration</subject><subject>Transducers</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonic Therapy - instrumentation</subject><subject>Ultrasonic Therapy - methods</subject><subject>Ultrasonic Therapy - veterinary</subject><subject>Ultrasonic transducers</subject><subject>Ultrasonics, quantum acoustics, and physical effects of sound</subject><subject>Ultrasound</subject><issn>0885-3010</issn><issn>1525-8955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><sourceid>EIF</sourceid><recordid>eNqF0c1rFDEYBvAgit1Wr14ECYJ6mvXNd3Isi6tCxUuLx5CZyawpM8mazBT87812Fwse7CmB_N438DwIvSKwJgTMx-ub7XazpgBqTYV6glZEUNFoI8RTtAKtRcOAwBk6L-UWgHBu6HN0RhSjmnFYoR_fUr-MLuPel7CLeEgZh4jvwl3CaT-Hzo04TG4X4g672ONlnLMraanXOXs3Tz7Oh4H5p8fTkkP0uM0uxBfo2eDG4l-ezgt0s_10vfnSXH3__HVzedV0XPK5oTBocANnrBta5ww3nBDHpDBeOtEBp1QT2raSCS5Nr4SnvSZVgZNG-4FdoA_Hvfucfi2-zHYKpfPj6KJPS7Fag5RKE1bl-_9KBbR-ptSjkNUQlSDwKKT1a80Vr_DtP_A2LTnWXKyWnComgVS0PqIup1KyH-w-1-Tzb0vAHrq2913bQ9e2dl0H3py2Lu3k-wd-KreCdyfgSu1xyC52oTw4zQ1oMNW9Prrgvf_7zAmomgn7A4blt-c</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Raymond, S.B.</creator><creator>Skoch, J.</creator><creator>Bacskai, B.J.</creator><creator>Hynynen, K.</creator><general>IEEE</general><general>Institute of Electrical and Electronics Engineers</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope><scope>7QO</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Modular design for in vivo optical imaging and ultrasound treatment in the murine brain</title><author>Raymond, S.B. ; Skoch, J. ; Bacskai, B.J. ; Hynynen, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-20f80af433cfbaa949411a3659e6a5c0422812bb635469d75e2d814940a698ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acoustic transducers</topic><topic>Acoustics</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomedical materials</topic><topic>Blood-brain barrier</topic><topic>Blood-Brain Barrier - cytology</topic><topic>Blood-Brain Barrier - radiation effects</topic><topic>Brain</topic><topic>Brain - cytology</topic><topic>Brain - radiation effects</topic><topic>Equipment Design</topic><topic>Equipment Failure Analysis</topic><topic>Exact sciences and technology</topic><topic>Focusing</topic><topic>Fundamental areas of phenomenology (including applications)</topic><topic>General equipment and techniques</topic><topic>Geometric constraints</topic><topic>Imaging</topic><topic>In vivo</topic><topic>In vivo testing</topic><topic>In vivo tests</topic><topic>Instruments, apparatus, components and techniques common to several branches of physics and astronomy</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microscopy</topic><topic>Microscopy, Fluorescence, Multiphoton - instrumentation</topic><topic>Microscopy, Fluorescence, Multiphoton - methods</topic><topic>Microscopy, Fluorescence, Multiphoton - veterinary</topic><topic>Miscellaneous. 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| ispartof | IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2007-02, Vol.54 (2), p.431-434 |
| issn | 0885-3010 1525-8955 |
| language | eng |
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| source | IEEE Electronic Library (IEL) |
| subjects | Acoustic transducers Acoustics Animals Biological and medical sciences Biomedical materials Blood-brain barrier Blood-Brain Barrier - cytology Blood-Brain Barrier - radiation effects Brain Brain - cytology Brain - radiation effects Equipment Design Equipment Failure Analysis Exact sciences and technology Focusing Fundamental areas of phenomenology (including applications) General equipment and techniques Geometric constraints Imaging In vivo In vivo testing In vivo tests Instruments, apparatus, components and techniques common to several branches of physics and astronomy Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Inbred C57BL Microscopy Microscopy, Fluorescence, Multiphoton - instrumentation Microscopy, Fluorescence, Multiphoton - methods Microscopy, Fluorescence, Multiphoton - veterinary Miscellaneous. Technology Optical design Optical imaging Physics Skull Sonication - instrumentation Systems Integration Transducers Ultrasonic imaging Ultrasonic investigative techniques Ultrasonic Therapy - instrumentation Ultrasonic Therapy - methods Ultrasonic Therapy - veterinary Ultrasonic transducers Ultrasonics, quantum acoustics, and physical effects of sound Ultrasound |
| title | Modular design for in vivo optical imaging and ultrasound treatment in the murine brain |
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