Modular design for in vivo optical imaging and ultrasound treatment in the murine brain

Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric constraints. We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope...

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Veröffentlicht in:	IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2007-02, Vol.54 (2), p.431-434
Hauptverfasser:	Raymond, S.B., Skoch, J., Bacskai, B.J., Hynynen, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic transducers Acoustics Animals Biological and medical sciences Biomedical materials Blood-brain barrier Blood-Brain Barrier - cytology Blood-Brain Barrier - radiation effects Brain Brain - cytology Brain - radiation effects Equipment Design Equipment Failure Analysis Exact sciences and technology Focusing Fundamental areas of phenomenology (including applications) General equipment and techniques Geometric constraints Imaging In vivo In vivo testing In vivo tests Instruments, apparatus, components and techniques common to several branches of physics and astronomy Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Inbred C57BL Microscopy Microscopy, Fluorescence, Multiphoton - instrumentation Microscopy, Fluorescence, Multiphoton - methods Microscopy, Fluorescence, Multiphoton - veterinary Miscellaneous. Technology Optical design Optical imaging Physics Skull Sonication - instrumentation Systems Integration Transducers Ultrasonic imaging Ultrasonic investigative techniques Ultrasonic Therapy - instrumentation Ultrasonic Therapy - methods Ultrasonic Therapy - veterinary Ultrasonic transducers Ultrasonics, quantum acoustics, and physical effects of sound Ultrasound
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Beschreibung
Zusammenfassung:	Simultaneous optical imaging and ultrasound exposure to the brain is challenging due to geometric constraints. We demonstrate sonication through the ventral surface of the mouse, leaving the dorsal aspect free for imaging. Ultrasound components are integrated into a commercial multiphoton microscope, and animals are imaged during ultrasound-induced blood-brain barrier disruption
ISSN:	0885-3010 1525-8955
DOI:	10.1109/TUFFC.2007.257