Peptides derived from nucleoside beta-amino acids form an unusual 8-helix

Peptides derived from nucleoside beta-amino acids form an unusual 8-helix

Peptides of varying length (dimers to octamers) were prepared from nucleoside beta-amino acids and conformational studies, based on NOE observations, show that the beta-peptides form an unusual 8-helix.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2008-01 (5), p.585-587
Hauptverfasser: Threlfall, Richard, Davies, Andrew, Howarth, Nicola M, Fisher, Julie, Cosstick, Richard
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - chemistry
Magnetic Resonance Spectroscopy - methods
Models, Molecular
Nucleic Acid Conformation
Nucleosides - chemistry
Peptides - chemistry
Protein Structure, Secondary
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Zusammenfassung:Peptides of varying length (dimers to octamers) were prepared from nucleoside beta-amino acids and conformational studies, based on NOE observations, show that the beta-peptides form an unusual 8-helix.
ISSN:1359-7345
1364-548X
DOI:10.1039/b714350h