Autologous Transplantation of the Retinal Pigment Epithelium and Choroid in the Treatment of Neovascular Age-Related Macular Degeneration

Purpose To assess excision of choroidal new vessels (CNV) combined with autologous transplantation of the equatorial retinal pigment epithelium (RPE) as a means of restoring vision for patients with acute neovascular age-related macular degeneration (AMD). Design Prospective interventional cohort st...

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Veröffentlicht in:	Ophthalmology (Rochester, Minn.) Minn.), 2007-03, Vol.114 (3), p.561-570.e2
Hauptverfasser:	MacLaren, Robert E., DPhil, FRCOphth, Uppal, Gurmit S., MRCOphth, Balaggan, Kamaljit S., MRCOphth, Tufail, Adnan, MD, FRCOphth, Munro, Peter M.G., PhD, Milliken, Andrew B., FCOptom, Ali, Robin R., PhD, Rubin, Gary S., PhD, Aylward, G. William, MD, FRCOphth, da Cruz, Lyndon, PhD, FRCOphth
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Biological and medical sciences Blood Vessels - pathology Cataract - complications Cataract Extraction Choroid - blood supply Choroid - transplantation Choroidal Neovascularization - complications Choroidal Neovascularization - surgery Cohort Studies Gene Transfer Techniques Green Fluorescent Proteins - genetics Humans In Vitro Techniques Macular Degeneration - complications Macular Degeneration - surgery Medical sciences Miscellaneous Ophthalmology Pigment Epithelium of Eye - transplantation Postoperative Complications Prospective Studies Rats Recovery of Function Severity of Illness Index Transplantation, Autologous Vision Disorders - etiology Vision Disorders - physiopathology Vision, Ocular
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Beschreibung
Zusammenfassung:	Purpose To assess excision of choroidal new vessels (CNV) combined with autologous transplantation of the equatorial retinal pigment epithelium (RPE) as a means of restoring vision for patients with acute neovascular age-related macular degeneration (AMD). Design Prospective interventional cohort study. Participants Twelve patients were recruited into an ethics committee approved trial with informed consent between 2004 and 2005. All had
ISSN:	0161-6420 1549-4713
DOI:	10.1016/j.ophtha.2006.06.049