Fabrication of Particulate Reservoir-Containing, Capsulelike, and Self-Folding Polymer Microstructures for Drug Delivery

Fabrication of Particulate Reservoir-Containing, Capsulelike, and Self-Folding Polymer Microstructures for Drug Delivery

Particulate polymer microdevices are fabricated using protocols based on a transfer‐molding process that allows the controlled assembly of multiple materials to produce functional devices. Specifically, protocols for reservoir‐containing (see image; scale bar=100 μm), capsulelike, and self‐folding p...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2007-03, Vol.3 (3), p.412-418
Hauptverfasser: Guan, Jingjiao, He, Hongyan, Lee, L. James, Hansford, Derek J.
Format: Artikel
Sprache:eng
Schlagworte:
Capsules - chemical synthesis
Crystallization - methods
Dimethylpolysiloxanes - chemistry
Drug Compounding - methods
drug delivery
Drug Delivery Systems - methods
Macromolecular Substances - chemistry
Materials Testing
microfabrication
microstructures
Molecular Conformation
Nanostructures - chemistry
Nanostructures - ultrastructure
Nanotechnology - methods
Particle Size
Polyethylene Glycols - chemistry
polymers
Polymethacrylic Acids - chemistry
soft lithography
Surface Properties
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Zusammenfassung:Particulate polymer microdevices are fabricated using protocols based on a transfer‐molding process that allows the controlled assembly of multiple materials to produce functional devices. Specifically, protocols for reservoir‐containing (see image; scale bar=100 μm), capsulelike, and self‐folding polymer microdevices are presented. The encapsulated materials are not exposed to high temperatures or caustic solutions, which is important in drug‐delivery applications.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.200600240