Enzymatic Control of the Size of DNA Block Copolymer Nanoparticles

Enzymatic Control of the Size of DNA Block Copolymer Nanoparticles

The right kind of upbringing: The size of DNA nanoparticles can be adjusted by an enzymatic reaction. By varying the incubation time of spherical nucleic acid block copolymer micelles (see picture) with a non‐template‐dependent DNA polymerase, the size of the nanoobjects can be gradually increased....

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-01, Vol.47 (5), p.974-976
Hauptverfasser: Alemdaroglu, Fikri E, Wang, Jie, Börsch, Michael, Berger, Rüdiger, Herrmann, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
bionanotechnology
block copolymers
DNA
DNA - chemistry
DNA Nucleotidylexotransferase - chemistry
enzymes
Nanoparticles - chemistry
nanostructures
Particle Size
Polymers - chemical synthesis
Polymers - chemistry
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Zusammenfassung:The right kind of upbringing: The size of DNA nanoparticles can be adjusted by an enzymatic reaction. By varying the incubation time of spherical nucleic acid block copolymer micelles (see picture) with a non‐template‐dependent DNA polymerase, the size of the nanoobjects can be gradually increased.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200703466