Deracemization of Secondary Alcohols through a Concurrent Tandem Biocatalytic Oxidation and Reduction
Breaking the mirror: A purified alcohol dehydrogenase (ADH) for stereoselective reduction and whole cells of a microorganism for enantioselective oxidation operated concurrently to effect the stereoinversion of one enantiomer of a racemic secondary alcohol and provide the optically pure alcohol in &...
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Veröffentlicht in: | Angewandte Chemie (International ed.) 2008-01, Vol.47 (4), p.741-745 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Breaking the mirror: A purified alcohol dehydrogenase (ADH) for stereoselective reduction and whole cells of a microorganism for enantioselective oxidation operated concurrently to effect the stereoinversion of one enantiomer of a racemic secondary alcohol and provide the optically pure alcohol in >99 % yield (see scheme). R,R′=alkyl. |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.200703296 |