Deracemization of Secondary Alcohols through a Concurrent Tandem Biocatalytic Oxidation and Reduction

Breaking the mirror: A purified alcohol dehydrogenase (ADH) for stereoselective reduction and whole cells of a microorganism for enantioselective oxidation operated concurrently to effect the stereoinversion of one enantiomer of a racemic secondary alcohol and provide the optically pure alcohol in &...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-01, Vol.47 (4), p.741-745
Hauptverfasser: Voss, Constance V, Gruber, Christian C, Kroutil, Wolfgang
Format: Artikel
Sprache:eng
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Zusammenfassung:Breaking the mirror: A purified alcohol dehydrogenase (ADH) for stereoselective reduction and whole cells of a microorganism for enantioselective oxidation operated concurrently to effect the stereoinversion of one enantiomer of a racemic secondary alcohol and provide the optically pure alcohol in >99 % yield (see scheme). R,R′=alkyl.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200703296