Overweight and Obesity at Different Times in Life as Risk Factors for Non-Hodgkin's Lymphoma: The Multiethnic Cohort
Obesity may increase the risk for non-Hodgkin's lymphoma (NHL) through an inflammatory pathway. We explored the relation of NHL with body size at different times in life within the Multiethnic Cohort that includes African Americans, Caucasians, Japanese, Latinos, and Native Hawaiians. Participa...
Gespeichert in:
Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2008-01, Vol.17 (1), p.196-203 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Obesity may increase the risk for non-Hodgkin's lymphoma (NHL) through an inflammatory pathway. We explored the relation of
NHL with body size at different times in life within the Multiethnic Cohort that includes African Americans, Caucasians, Japanese,
Latinos, and Native Hawaiians. Participants were 45 to 75 years old at recruitment in 1993 to 1996. This analysis included
87,079 men and 105,972 women with 461 male and 378 female NHL cases. We used Cox regression to model NHL risk with age as
the time metric while adjusting for age at baseline, ethnicity, education, alcohol intake, and age at first live birth. Body
weight and body mass index at age 21 were stronger predictors of NHL risk than anthropometric characteristics at baseline.
For men, being in the highest quartile of body mass index and body weight at age 21 conferred a nonsignificant 86% and 41%
higher NHL risk, respectively, whereas there was no association at baseline. For women, the risk associated with the highest
quartile of weight at age 21 was 1.6 ( P trend = 0.04), whereas women in the highest quartile at baseline had a nonsignificant risk of 27%. Height was positively related
to NHL in men and women. Despite the small numbers, there was some consistency for risk estimates across ethnic groups and
weak evidence for an association with NHL subtypes. These findings indicate that weight at age 21 may represent lifetime adiposity
better than body weight at cohort entry. Alternatively, weight at age 21 may be more relevant for the etiology of NHL. (Cancer
Epidemiol Biomarkers Prev 2008;17(1):196–203) |
---|---|
ISSN: | 1055-9965 1538-7755 |
DOI: | 10.1158/1055-9965.EPI-07-0716 |