Inhibition of Hep2 and HeLa cell proliferation in vitro and EAC tumor growth in vivo by Lapemis curtus (Shaw 1802) venom

The antitumor activity of the sea snake venom ( Lapemis curtus) was evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different doses tested, 6.50 μg/ml at 24 h was found to effectively inhibit cancer cell proliferation. Th...

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Veröffentlicht in:	Toxicon (Oxford) 2008, Vol.51 (1), p.157-161
Hauptverfasser:	Karthikeyan, R., Karthigayan, S., Sri Balasubashini, M., Somasundaram, S.T., Balasubramanian, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Animals Antineoplastic Agents - pharmacology Antitumor Biological and medical sciences Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - pathology Cell Line, Tumor Cell Proliferation - drug effects Cytotoxicity Ehrlich's ascites carcinoma Elapid Venoms - pharmacology Gastroenterology. Liver. Pancreas. Abdomen HeLa Cells Humans Lapemis curtus Medical sciences Mice Other diseases. Semiology Sea snake venom Time Factors
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Zusammenfassung:	The antitumor activity of the sea snake venom ( Lapemis curtus) was evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different doses tested, 6.50 μg/ml at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 201.25%.
ISSN:	0041-0101 1879-3150
DOI:	10.1016/j.toxicon.2007.08.012