Nine novel C-21 steroidal glycosides substituted with orthoacetate from Dregea sinensis var. corrugata

Nine novel steroidal glycosides substituted with the orthoacetate groups, compounds 1– 5 based on the aglycon of 12- O-acetyl-20- O-benzoyl-dihydrosarcostin 8,14,18-orthoacetate and compounds 6– 9 based on the aglycon of 12- O-acetyl-20- O-benzoyl-dihydrosarcostin 14,17,18-orthoacetate, were isolate...

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Veröffentlicht in:	Steroids 2008-02, Vol.73 (2), p.184-192
Hauptverfasser:	Liu, Yunbao, Qu, Jing, Yu, Shishan, Tang, Wenzhao, Liu, Jing, Hu, Youcai, Ma, Shuanggang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Asclepiadaceae Biological and medical sciences Dregea sinensis var. corrugata Fundamental and applied biological sciences. Psychology Glycosides - chemistry Glycosides - isolation & purification Molecular Structure Orthoacetate Plants, Medicinal - chemistry Spectrum Analysis Steroidal glycosides Steroids - chemistry Steroids - isolation & purification Structure-Activity Relationship Vertebrates: endocrinology
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Zusammenfassung:	Nine novel steroidal glycosides substituted with the orthoacetate groups, compounds 1– 5 based on the aglycon of 12- O-acetyl-20- O-benzoyl-dihydrosarcostin 8,14,18-orthoacetate and compounds 6– 9 based on the aglycon of 12- O-acetyl-20- O-benzoyl-dihydrosarcostin 14,17,18-orthoacetate, were isolated from Dregea sinensis var. corrugata. Their structures were deduced on the basis of chemical and spectral evidences. Compound 1 showed moderate anti-inflammatory activity.
ISSN:	0039-128X 1878-5867
DOI:	10.1016/j.steroids.2007.09.009