Survival Analysis of 130 Patients with Papillary Renal Cell Carcinoma: Prognostic Utility of Type 1 and Type 2 Subclassification

Objectives To evaluate the prognostic significance of subtyping papillary renal cell carcinoma (PRCC) into type 1 and type 2 tumors. Methods From 1995 to 2004, 1358 patients underwent surgery for renal cell carcinoma, of whom 130 had PRCC alone on the specimen. The tumor characteristics, including t...

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Veröffentlicht in:Urology (Ridgewood, N.J.) N.J.), 2007-02, Vol.69 (2), p.230-235
Hauptverfasser: Pignot, Géraldine, Elie, Caroline, Conquy, Sophie, Vieillefond, Annick, Flam, Thierry, Zerbib, Marc, Debré, Bernard, Amsellem-Ouazana, Delphine
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Sprache:eng
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Zusammenfassung:Objectives To evaluate the prognostic significance of subtyping papillary renal cell carcinoma (PRCC) into type 1 and type 2 tumors. Methods From 1995 to 2004, 1358 patients underwent surgery for renal cell carcinoma, of whom 130 had PRCC alone on the specimen. The tumor characteristics, including their subtype, were analyzed; small basophilic cells and large eosinophilic cells were defined type 1 and type 2 tumors, respectively. Survival analyses were performed retrospectively. Results Of the 130 patients (110 men and 20 women, mean age 60.6 ± 15.3 years) with PRCC, 102 underwent radical nephrectomy (78.4%) and 28 underwent partial nephrectomy (21.6%). The median tumor size was 4.5 cm (range 0.5 to 21). The comparison of the 68 (52.3%) type 1 PRCCs and 62 (47.7%) type 2 PRCCs revealed that type 2 tumors were associated with a greater stage and grade and microvascular invasion significantly ( P
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2006.09.052