Fluorine in medicinal chemistry

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical Society reviews 2008-02, Vol.37 (2), p.320-330
Hauptverfasser:	Purser, Sophie, Moore, Peter R, Swallow, Steve, Gouverneur, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Pharmaceutical Drug Design Humans Hydrocarbons, Fluorinated - chemistry Hydrocarbons, Fluorinated - pharmacology Molecular Structure Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
ISSN:	0306-0012 1460-4744
DOI:	10.1039/b610213c