Design and Synthesis of Cyclic RGD Pentapeptoids by Consecutive Ugi Reactions

A new strategy for the synthesis of cyclic peptoids was developed. The approach is based on the use of consecutive Ugi reactions for the assembly of the acyclic peptoid and for the ring closure. Cyclopentapeptoid analogues of the RGD peptides were designed and synthesized using this methodology. The...

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Veröffentlicht in:	Organic letters 2008-01, Vol.10 (2), p.205-208
Hauptverfasser:	Vercillo, Otilie E, Andrade, Carlos Kleber Z, Wessjohann, Ludger A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclization Models, Molecular Molecular Structure Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptoids - chemical synthesis Peptoids - chemistry
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Beschreibung
Zusammenfassung:	A new strategy for the synthesis of cyclic peptoids was developed. The approach is based on the use of consecutive Ugi reactions for the assembly of the acyclic peptoid and for the ring closure. Cyclopentapeptoid analogues of the RGD peptides were designed and synthesized using this methodology. The results confirm the versatility and efficiency of the method for the preparation of cyclic oligopeptoids.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol702521g