Novel approaches to the treatment of cachexia

Cachexia is a complex syndrome. The main components of this pathological state are anorexia and metabolic abnormalities, such as glucose intolerance, fat depletion and muscle protein catabolism among others. The aim of the present article is to review the recent therapeutic approaches that have been...

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Veröffentlicht in:	Drug discovery today 2008, Vol.13 (1), p.73-78
Hauptverfasser:	Argilés, Josep M., López-Soriano, Francisco J., Busquets, Sílvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Appetite Stimulants - therapeutic use Biological and medical sciences Cachexia - drug therapy Cachexia - etiology Cachexia - metabolism Chronic Disease Drug Therapy, Combination General pharmacology Heart Failure - complications Heart Failure - metabolism HIV Wasting Syndrome - complications HIV Wasting Syndrome - metabolism Humans Medical sciences Neoplasms - complications Neoplasms - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	Cachexia is a complex syndrome. The main components of this pathological state are anorexia and metabolic abnormalities, such as glucose intolerance, fat depletion and muscle protein catabolism among others. The aim of the present article is to review the recent therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure.
ISSN:	1359-6446 1878-5832
DOI:	10.1016/j.drudis.2007.10.008