Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration
Abstract Paraneoplastic cerebellar degeneration (PCD) is linked to an immune response against cerebellar degeneration related antigen 2 (cdr2) co-expressed in tumor and Purkinje neurons. Here, comprehensive immune-assessment assays were used to analyze CD8+ T cells from 7 PCD patients, but no eviden...
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Veröffentlicht in: | Journal of neuroimmunology 2008-01, Vol.193 (1), p.173-182 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Abstract Paraneoplastic cerebellar degeneration (PCD) is linked to an immune response against cerebellar degeneration related antigen 2 (cdr2) co-expressed in tumor and Purkinje neurons. Here, comprehensive immune-assessment assays were used to analyze CD8+ T cells from 7 PCD patients, but no evidence was found of CD8+ T cells specific for either of two previously described cdr2 epitopes (cdr2-1 and cdr2-2). In contrast, viral-specific CD8+ T cells from healthy volunteers and PCD patients were measurable. These findings are inconsistent with an obligate role for cdr2-1- or cdr2-2-specific CD8+ T cells in the pathogenesis of PCD. |
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ISSN: | 0165-5728 1872-8421 |
DOI: | 10.1016/j.jneuroim.2007.10.014 |