Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as new rubella virus inhibitors
In the search for new chemotherapeutic agents useful against Rubella virus (RV) infections, a solution-phase parallel approach for the synthesis of a small library of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines has been set up, based on previous results from our research group. Biologica...
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| Veröffentlicht in: | European journal of medicinal chemistry 2007-02, Vol.42 (2), p.256-262 |
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| container_title | European journal of medicinal chemistry |
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| creator | Mugnaini, Claudia Petricci, Elena Botta, Maurizio Corelli, Federico Mastromarino, Paola Giorgi, Gianluca |
| description | In the search for new chemotherapeutic agents useful against Rubella virus (RV) infections, a solution-phase parallel approach for the synthesis of a small library of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines has been set up, based on previous results from our research group. Biological evaluation of the newly synthesized compounds pointed out their interesting properties as anti-RV agents with IC
50 values in the micromolar range.
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| doi_str_mv | 10.1016/j.ejmech.2006.09.002 |
| format | Article |
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50 values in the micromolar range.
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Drug treatments</subject><subject>Pyrimidines - chemical synthesis</subject><subject>Pyrimidines - chemistry</subject><subject>Pyrimidines - pharmacology</subject><subject>Rubella virus</subject><subject>Rubella virus - drug effects</subject><subject>Solid-supported scavengers</subject><subject>Structure-Activity Relationship</subject><subject>Vero Cells</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD2P1DAQhi0E4paDf4BQGhAUDhM7duIGCZ34kk6iAGrLsWeJl8Re7GQhDb-dhF3pOiqPrGfemXkIeVpBWUElXx9KPIxo-5IByBJUCcDukV3VyJZyJur7ZAeMcSoYr6_Io5wPACAkwENyVTVQCy7rHfnzZQlTj9nnwgRXdD4O8bu3ZijwZIbZTD6GIu6LmprhxzKY0YdIJX3JaL-4FH8vOPXL8IoyOv6rpt7H45L86J0PuIbmIuCvIs0dDoMpTj7NufCh952fYsqPyYO9GTI-ubzX5Nv7d19vPtLbzx8-3by9pZYrmNYbpHStRbCd7JQBJUC262fTKSe5RCeYaLDhUgBvOwet5dbVSmAnGt6A5NfkxTn3mOLPGfOkR5_ttlLAOGfdQKWUYhtYn0GbYs4J9_q4HmPSoivQm3d90GfvevOuQenV-9r27JI_dyO6u6aL6BV4fgFMXu3ukwnW5zuuFS0XzTb_zZnD1cbJY9LZegwWnU9oJ-2i__8mfwEnHaQF</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Mugnaini, Claudia</creator><creator>Petricci, Elena</creator><creator>Botta, Maurizio</creator><creator>Corelli, Federico</creator><creator>Mastromarino, Paola</creator><creator>Giorgi, Gianluca</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as new rubella virus inhibitors</title><author>Mugnaini, Claudia ; Petricci, Elena ; Botta, Maurizio ; Corelli, Federico ; Mastromarino, Paola ; Giorgi, Gianluca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-5266d8ce0cb6b9a0950685267b9d636ed5257e7365038bd08c3cd495eb5737063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>2,4,6-Trisubstituted pyrimidines</topic><topic>Animals</topic><topic>Antibiotics. 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Biological evaluation of the newly synthesized compounds pointed out their interesting properties as anti-RV agents with IC
50 values in the micromolar range.
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| subjects | 2,4,6-Trisubstituted pyrimidines Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cercopithecus aethiops Medical sciences Parallel synthesis Pharmacology. Drug treatments Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Rubella virus Rubella virus - drug effects Solid-supported scavengers Structure-Activity Relationship Vero Cells |
| title | Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as new rubella virus inhibitors |
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