Synthesis and biological evaluation of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines as new rubella virus inhibitors

In the search for new chemotherapeutic agents useful against Rubella virus (RV) infections, a solution-phase parallel approach for the synthesis of a small library of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines has been set up, based on previous results from our research group. Biologica...

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Veröffentlicht in:	European journal of medicinal chemistry 2007-02, Vol.42 (2), p.256-262
Hauptverfasser:	Mugnaini, Claudia, Petricci, Elena, Botta, Maurizio, Corelli, Federico, Mastromarino, Paola, Giorgi, Gianluca
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4,6-Trisubstituted pyrimidines Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cercopithecus aethiops Medical sciences Parallel synthesis Pharmacology. Drug treatments Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Rubella virus Rubella virus - drug effects Solid-supported scavengers Structure-Activity Relationship Vero Cells
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Zusammenfassung:	In the search for new chemotherapeutic agents useful against Rubella virus (RV) infections, a solution-phase parallel approach for the synthesis of a small library of 4-alkylamino-6-(2-hydroxyethyl)-2-methylthiopyrimidines has been set up, based on previous results from our research group. Biological evaluation of the newly synthesized compounds pointed out their interesting properties as anti-RV agents with IC 50 values in the micromolar range. [Display omitted]
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2006.09.002