Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm DNA fragmentation

Objective Potential reparation of sperm DNA fragmentation in the oocyte may disturb any relationship between DNA-damaged sperm and the implantation ability of resulting embryos. To rule out this factor, we analyzed the consequences of sperm DNA fragmentation on IVF-ET outcome in women with healthy o...

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Veröffentlicht in:	Fertility and sterility 2008, Vol.89 (1), p.92-97
Hauptverfasser:	Frydman, Nelly, Pharm.D, Prisant, Nadia, M.D, Hesters, Laetitia, Pharm.D, Frydman, René, Ph.D, Tachdjian, Gérard, Ph.D, Cohen-Bacrie, Paul, Pharm.D, Fanchin, Rénato, Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Conventional IVF DNA Fragmentation DNA Repair Embryo Implantation Embryo Transfer Female Fertilization in Vitro Flow Cytometry Gynecology. Andrology. Obstetrics Humans In Situ Nick-End Labeling Infertility, Female - genetics Infertility, Female - metabolism Infertility, Female - pathology Infertility, Female - physiopathology Infertility, Female - therapy Internal Medicine Male Medical sciences Obstetrics and Gynecology ongoing pregnancy rate Ovarian Follicle - metabolism Ovulation Induction Pregnancy Pregnancy Rate Prospective Studies sperm DNA fragmentation Sperm-Ovum Interactions Spermatozoa - metabolism Spermatozoa - pathology Treatment Outcome TUNEL assay
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Zusammenfassung:	Objective Potential reparation of sperm DNA fragmentation in the oocyte may disturb any relationship between DNA-damaged sperm and the implantation ability of resulting embryos. To rule out this factor, we analyzed the consequences of sperm DNA fragmentation on IVF-ET outcome in women with healthy ovarian function. Design Prospective study. Setting Teaching hospital, France. Patient(s) All 117 women were
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2007.02.022