Interventricular mechanical dyssynchrony: A novel marker of cardiac events in Brugada syndrome

Background Risk stratification in Brugada syndrome is controversial, especially in asymptomatic individuals. Objective The purpose of this study was to evaluate tissue Doppler echocardiography in risk stratification of Brugada syndrome. Methods Patients with Brugada ECG pattern were enrolled in the study. Left ventricular (LV) preejection period was defined as the time interval between onset of the QRS complex and onset of LV lateral wall systolic wave. Right ventricular (RV) preejection period was defined as the time interval between onset of the QRS complex and onset of RV lateral wall systolic wave. Delay in onset of contraction between RV and LV was defined as RV preejection time − LV preejection time [PET(RV–LV) ]. Results Type 1, 2, and 3 Brugada ECG pattern was found in 30, 56, and 31 patients, respectively. PET(RV–LV) was significantly greater in type 1 Brugada patients (39.2 ± 3.2 ms) compared with type 2 (5 ± 0.3 ms) and 3 (5 ± 0.4 ms) Brugada patients as well as controls (4.6 ± 0.3 ms, P