A new chemical tool for exploring the physiological function of the PDE2 isozyme

Oxindole ( 2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2. Oxindole ( 2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-01, Vol.16 (2), p.307-310
Hauptverfasser:	Chambers, Robert J., Abrams, Kristin, Garceau, Norman Y., Kamath, Ajith V., Manley, Christopher M., Lilley, Susan C., Otte, Douglas A., Scott, Dennis O., Sheils, Alissa L., Tess, David A., Vellekoop, A. Samuel, Zhang, Yan, Lam, Kelvin T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Administration, Oral Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cyclic Nucleotide Phosphodiesterases, Type 2 Drug Evaluation, Preclinical Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacokinetics Isoenzymes - drug effects Isoenzymes - physiology Medical sciences Miscellaneous Molecular Structure PDE2 Pharmacology. Drug treatments Phosphodiesterase Phosphodiesterase Inhibitors - chemical synthesis Phosphodiesterase Inhibitors - chemistry Phosphodiesterase Inhibitors - pharmacokinetics Phosphoric Diester Hydrolases - drug effects Phosphoric Diester Hydrolases - physiology Rats Solubility Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Oxindole ( 2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2. Oxindole ( 2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.10.005