In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists : Trends across multiple chemical series

Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolid...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2008, Vol.18 (1), p.355-359
Hauptverfasser:	NERSESIAN, Diana L, BLACK, Lawrence A, MILLER, Thomas R, VORTHERMS, Timothy A, ESBENSHADE, Timothy A, HANCOCK, Arthur A, COWART, Marlon D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Histamine H3 Antagonists - chemistry Histamine H3 Antagonists - pharmacology Humans Kinetics Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyrrolidines - chemistry Pyrrolidines - pharmacology Rats Structure-Activity Relationship
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Zusammenfassung:	Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.10.067