Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Cynomolgus Monkeys Using the Bravo® pH System
Purpose To measure fasted and fed gastric pH and gastric residence time (GRT) in Cynomolgus monkeys using Bravo® radiotelemetry capsules. Methods Continuous pH measurements were recorded with Bravo® capsules, which were either attached to the monkeys’ stomach or administered as free capsules. Meals...
Gespeichert in:
| Veröffentlicht in: | Pharmaceutical research 2008-01, Vol.25 (1), p.123-134 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 134 |
|---|---|
| container_issue | 1 |
| container_start_page | 123 |
| container_title | Pharmaceutical research |
| container_volume | 25 |
| creator | Chen, Emile P. Mahar Doan, Kelly M. Portelli, Samm Coatney, Robert Vaden, Vernal Shi, Wei |
| description | Purpose
To measure fasted and fed gastric pH and gastric residence time (GRT) in Cynomolgus monkeys using Bravo® radiotelemetry capsules.
Methods
Continuous pH measurements were recorded with Bravo® capsules, which were either attached to the monkeys’ stomach or administered as free capsules. Meals (either slurry or standard), were administered at designated times with monkeys chair-restrained during slurry meal ingestion.
Results
From the attached capsule studies, the fasted gastric pH (∼1.9–2.2) was consistent among monkeys. Under fasted conditions, pH spikes were infrequently observed (once every 7.9 min to 3.6 h) with peaks reaching pH 9.4 and having short durations ( |
| doi_str_mv | 10.1007/s11095-007-9358-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70190879</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70190879</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-272f8d3a1f04ad56cb70854895668fe07a39640076ee727f82e8629ff00a10443</originalsourceid><addsrcrecordid>eNp1kd1qVDEUhYModlp9AG8kCHp3dCcnv5c6dFqhImgL3oU0JxlTz0mmyUxhXsqH6JOZcUYLgld7h_3tlZUshF4QeEsA5LtKCGjetbbTPVcdf4RmhMu-08C-PUYzkJR1SjJyhI5rvQEARTR7io6IFIRKLWZodWbrukSHV-fYpgH_OX7xNQ4-OY8v4-RxTHjRJn74DS1anedUXcybiufblKc8Llv7KacfflvxVY1pidffPf5Q7F2-_7mT_7ptAtMz9CTYsfrnh3qCrhanl_Pz7uLz2cf5-4vOMcHXHZU0qKG3JACzAxfuWoLiTGkuhAoepO21YO3lwntJZVDUK0F1CACWAGP9CXqz112VfLvxdW2mWJ0fR5t8c20kEA1K6ga--ge8yZuSmjdDabPRUy4aRPaQK7nW4oNZlTjZsjUEzC4Ls8_C7NpdFoa3nZcH4c315IeHjcPnN-D1AbDV2TEUm1ysfzkKhPRCycbRPVfbKC19eXD4_9t_AYLhoAA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222723256</pqid></control><display><type>article</type><title>Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Cynomolgus Monkeys Using the Bravo® pH System</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Chen, Emile P. ; Mahar Doan, Kelly M. ; Portelli, Samm ; Coatney, Robert ; Vaden, Vernal ; Shi, Wei</creator><creatorcontrib>Chen, Emile P. ; Mahar Doan, Kelly M. ; Portelli, Samm ; Coatney, Robert ; Vaden, Vernal ; Shi, Wei</creatorcontrib><description>Purpose
To measure fasted and fed gastric pH and gastric residence time (GRT) in Cynomolgus monkeys using Bravo® radiotelemetry capsules.
Methods
Continuous pH measurements were recorded with Bravo® capsules, which were either attached to the monkeys’ stomach or administered as free capsules. Meals (either slurry or standard), were administered at designated times with monkeys chair-restrained during slurry meal ingestion.
Results
From the attached capsule studies, the fasted gastric pH (∼1.9–2.2) was consistent among monkeys. Under fasted conditions, pH spikes were infrequently observed (once every 7.9 min to 3.6 h) with peaks reaching pH 9.4 and having short durations (<1 min). After feeding, the gastric pH rose quickly and remained alkaline for approximately 4.5–7.5 h before returning to baseline. Although significantly different (
p
< 0.05), there was overlap between the fasted (153 ± 87 min) and fed (436 ± 265 (slurry) and 697 ± 193 (standard) min) GRT due to considerable inter- and intra-subject variability.
Conclusions
Fasted gastric pH was similar between monkeys and literature human values. After a meal, the monkey gastric pH was elevated for a longer duration than that in human. The monkey GRT appears longer than that observed in human under both fasted and fed conditions, although this is likely dependent on the Bravo® capsule size.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1007/s11095-007-9358-5</identifier><identifier>PMID: 17612796</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biochemistry ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biotelemetry ; Capsules ; Data Interpretation, Statistical ; Fasting - physiology ; Food ; Gastric Acidity Determination - instrumentation ; Gastric Emptying - physiology ; Gastroenterology ; General pharmacology ; Hydrogen-Ion Concentration ; Macaca fascicularis ; Male ; Medical Law ; Medical sciences ; Monkeys & apes ; Pharmaceutical technology. Pharmaceutical industry ; Pharmaceuticals ; Pharmacology ; Pharmacology. Drug treatments ; Pharmacology/Toxicology ; Pharmacy ; Radiology ; Research Paper ; Stomach - metabolism ; Telemetry - methods</subject><ispartof>Pharmaceutical research, 2008-01, Vol.25 (1), p.123-134</ispartof><rights>Springer Science+Business Media, LLC 2007</rights><rights>2008 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-272f8d3a1f04ad56cb70854895668fe07a39640076ee727f82e8629ff00a10443</citedby><cites>FETCH-LOGICAL-c465t-272f8d3a1f04ad56cb70854895668fe07a39640076ee727f82e8629ff00a10443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11095-007-9358-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11095-007-9358-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20113687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17612796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Emile P.</creatorcontrib><creatorcontrib>Mahar Doan, Kelly M.</creatorcontrib><creatorcontrib>Portelli, Samm</creatorcontrib><creatorcontrib>Coatney, Robert</creatorcontrib><creatorcontrib>Vaden, Vernal</creatorcontrib><creatorcontrib>Shi, Wei</creatorcontrib><title>Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Cynomolgus Monkeys Using the Bravo® pH System</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><addtitle>Pharm Res</addtitle><description>Purpose
To measure fasted and fed gastric pH and gastric residence time (GRT) in Cynomolgus monkeys using Bravo® radiotelemetry capsules.
Methods
Continuous pH measurements were recorded with Bravo® capsules, which were either attached to the monkeys’ stomach or administered as free capsules. Meals (either slurry or standard), were administered at designated times with monkeys chair-restrained during slurry meal ingestion.
Results
From the attached capsule studies, the fasted gastric pH (∼1.9–2.2) was consistent among monkeys. Under fasted conditions, pH spikes were infrequently observed (once every 7.9 min to 3.6 h) with peaks reaching pH 9.4 and having short durations (<1 min). After feeding, the gastric pH rose quickly and remained alkaline for approximately 4.5–7.5 h before returning to baseline. Although significantly different (
p
< 0.05), there was overlap between the fasted (153 ± 87 min) and fed (436 ± 265 (slurry) and 697 ± 193 (standard) min) GRT due to considerable inter- and intra-subject variability.
Conclusions
Fasted gastric pH was similar between monkeys and literature human values. After a meal, the monkey gastric pH was elevated for a longer duration than that in human. The monkey GRT appears longer than that observed in human under both fasted and fed conditions, although this is likely dependent on the Bravo® capsule size.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Biotelemetry</subject><subject>Capsules</subject><subject>Data Interpretation, Statistical</subject><subject>Fasting - physiology</subject><subject>Food</subject><subject>Gastric Acidity Determination - instrumentation</subject><subject>Gastric Emptying - physiology</subject><subject>Gastroenterology</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Macaca fascicularis</subject><subject>Male</subject><subject>Medical Law</subject><subject>Medical sciences</subject><subject>Monkeys & apes</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmaceuticals</subject><subject>Pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Radiology</subject><subject>Research Paper</subject><subject>Stomach - metabolism</subject><subject>Telemetry - methods</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kd1qVDEUhYModlp9AG8kCHp3dCcnv5c6dFqhImgL3oU0JxlTz0mmyUxhXsqH6JOZcUYLgld7h_3tlZUshF4QeEsA5LtKCGjetbbTPVcdf4RmhMu-08C-PUYzkJR1SjJyhI5rvQEARTR7io6IFIRKLWZodWbrukSHV-fYpgH_OX7xNQ4-OY8v4-RxTHjRJn74DS1anedUXcybiufblKc8Llv7KacfflvxVY1pidffPf5Q7F2-_7mT_7ptAtMz9CTYsfrnh3qCrhanl_Pz7uLz2cf5-4vOMcHXHZU0qKG3JACzAxfuWoLiTGkuhAoepO21YO3lwntJZVDUK0F1CACWAGP9CXqz112VfLvxdW2mWJ0fR5t8c20kEA1K6ga--ge8yZuSmjdDabPRUy4aRPaQK7nW4oNZlTjZsjUEzC4Ls8_C7NpdFoa3nZcH4c315IeHjcPnN-D1AbDV2TEUm1ysfzkKhPRCycbRPVfbKC19eXD4_9t_AYLhoAA</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Chen, Emile P.</creator><creator>Mahar Doan, Kelly M.</creator><creator>Portelli, Samm</creator><creator>Coatney, Robert</creator><creator>Vaden, Vernal</creator><creator>Shi, Wei</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Cynomolgus Monkeys Using the Bravo® pH System</title><author>Chen, Emile P. ; Mahar Doan, Kelly M. ; Portelli, Samm ; Coatney, Robert ; Vaden, Vernal ; Shi, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-272f8d3a1f04ad56cb70854895668fe07a39640076ee727f82e8629ff00a10443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Biotelemetry</topic><topic>Capsules</topic><topic>Data Interpretation, Statistical</topic><topic>Fasting - physiology</topic><topic>Food</topic><topic>Gastric Acidity Determination - instrumentation</topic><topic>Gastric Emptying - physiology</topic><topic>Gastroenterology</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Macaca fascicularis</topic><topic>Male</topic><topic>Medical Law</topic><topic>Medical sciences</topic><topic>Monkeys & apes</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmaceuticals</topic><topic>Pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Radiology</topic><topic>Research Paper</topic><topic>Stomach - metabolism</topic><topic>Telemetry - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Emile P.</creatorcontrib><creatorcontrib>Mahar Doan, Kelly M.</creatorcontrib><creatorcontrib>Portelli, Samm</creatorcontrib><creatorcontrib>Coatney, Robert</creatorcontrib><creatorcontrib>Vaden, Vernal</creatorcontrib><creatorcontrib>Shi, Wei</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Emile P.</au><au>Mahar Doan, Kelly M.</au><au>Portelli, Samm</au><au>Coatney, Robert</au><au>Vaden, Vernal</au><au>Shi, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Cynomolgus Monkeys Using the Bravo® pH System</atitle><jtitle>Pharmaceutical research</jtitle><stitle>Pharm Res</stitle><addtitle>Pharm Res</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>25</volume><issue>1</issue><spage>123</spage><epage>134</epage><pages>123-134</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>Purpose
To measure fasted and fed gastric pH and gastric residence time (GRT) in Cynomolgus monkeys using Bravo® radiotelemetry capsules.
Methods
Continuous pH measurements were recorded with Bravo® capsules, which were either attached to the monkeys’ stomach or administered as free capsules. Meals (either slurry or standard), were administered at designated times with monkeys chair-restrained during slurry meal ingestion.
Results
From the attached capsule studies, the fasted gastric pH (∼1.9–2.2) was consistent among monkeys. Under fasted conditions, pH spikes were infrequently observed (once every 7.9 min to 3.6 h) with peaks reaching pH 9.4 and having short durations (<1 min). After feeding, the gastric pH rose quickly and remained alkaline for approximately 4.5–7.5 h before returning to baseline. Although significantly different (
p
< 0.05), there was overlap between the fasted (153 ± 87 min) and fed (436 ± 265 (slurry) and 697 ± 193 (standard) min) GRT due to considerable inter- and intra-subject variability.
Conclusions
Fasted gastric pH was similar between monkeys and literature human values. After a meal, the monkey gastric pH was elevated for a longer duration than that in human. The monkey GRT appears longer than that observed in human under both fasted and fed conditions, although this is likely dependent on the Bravo® capsule size.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>17612796</pmid><doi>10.1007/s11095-007-9358-5</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0724-8741 |
| ispartof | Pharmaceutical research, 2008-01, Vol.25 (1), p.123-134 |
| issn | 0724-8741 1573-904X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70190879 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biotelemetry Capsules Data Interpretation, Statistical Fasting - physiology Food Gastric Acidity Determination - instrumentation Gastric Emptying - physiology Gastroenterology General pharmacology Hydrogen-Ion Concentration Macaca fascicularis Male Medical Law Medical sciences Monkeys & apes Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Radiology Research Paper Stomach - metabolism Telemetry - methods |
| title | Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Cynomolgus Monkeys Using the Bravo® pH System |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T03%3A34%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gastric%20pH%20and%20Gastric%20Residence%20Time%20in%20Fasted%20and%20Fed%20Conscious%20Cynomolgus%20Monkeys%20Using%20the%20Bravo%C2%AE%20pH%20System&rft.jtitle=Pharmaceutical%20research&rft.au=Chen,%20Emile%20P.&rft.date=2008-01-01&rft.volume=25&rft.issue=1&rft.spage=123&rft.epage=134&rft.pages=123-134&rft.issn=0724-8741&rft.eissn=1573-904X&rft.coden=PHREEB&rft_id=info:doi/10.1007/s11095-007-9358-5&rft_dat=%3Cproquest_cross%3E70190879%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222723256&rft_id=info:pmid/17612796&rfr_iscdi=true |