Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Cynomolgus Monkeys Using the Bravo® pH System

Purpose To measure fasted and fed gastric pH and gastric residence time (GRT) in Cynomolgus monkeys using Bravo® radiotelemetry capsules. Methods Continuous pH measurements were recorded with Bravo® capsules, which were either attached to the monkeys’ stomach or administered as free capsules. Meals...

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Veröffentlicht in:	Pharmaceutical research 2008-01, Vol.25 (1), p.123-134
Hauptverfasser:	Chen, Emile P., Mahar Doan, Kelly M., Portelli, Samm, Coatney, Robert, Vaden, Vernal, Shi, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biotelemetry Capsules Data Interpretation, Statistical Fasting - physiology Food Gastric Acidity Determination - instrumentation Gastric Emptying - physiology Gastroenterology General pharmacology Hydrogen-Ion Concentration Macaca fascicularis Male Medical Law Medical sciences Monkeys & apes Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Radiology Research Paper Stomach - metabolism Telemetry - methods
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Zusammenfassung:	Purpose To measure fasted and fed gastric pH and gastric residence time (GRT) in Cynomolgus monkeys using Bravo® radiotelemetry capsules. Methods Continuous pH measurements were recorded with Bravo® capsules, which were either attached to the monkeys’ stomach or administered as free capsules. Meals (either slurry or standard), were administered at designated times with monkeys chair-restrained during slurry meal ingestion. Results From the attached capsule studies, the fasted gastric pH (∼1.9–2.2) was consistent among monkeys. Under fasted conditions, pH spikes were infrequently observed (once every 7.9 min to 3.6 h) with peaks reaching pH 9.4 and having short durations (
ISSN:	0724-8741 1573-904X
DOI:	10.1007/s11095-007-9358-5