Sulfonate chalcone as new class voltage-dependent K + channel blocker

Sulfonate Chalcones 9– 17 were found to exhibit the potential to act as a new class of voltage-dependent K + channel blockers. Chalcone derivatives 1– 17 were synthesized and their voltage-dependent K + channel inhibitory activities were investigated. The effective K + channel blockers were shown to be sulfonate chalcones 9– 17, in which the sulfonyloxy group is placed on the A-ring. The 3′-( p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC 50 = 0.51 ± 0.05 μM) was the most potent K + channel blocker.