The identification of potent and selective imidazole-based inhibitors of B-Raf kinase

A novel triarylimidazole derivative, SB-590885 ( 33), bearing a 2,3-dihydro-1 H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase. A novel triarylimidazole derivative, SB-590885 ( 33), bearing a 2,3-dihydro-1 H-inden-1-one oxime substitue...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-01, Vol.16 (2), p.378-381
Hauptverfasser:	Takle, Andrew K., Brown, Murray J.B., Davies, Susannah, Dean, David K., Francis, Gerraint, Gaiba, Alessandra, Hird, Alex W., King, Frank D., Lovell, Peter J., Naylor, Antoinette, Reith, Alastair D., Steadman, Jon G., Wilson, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Raf Biological and medical sciences Cyclization Imidazole Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Medical sciences Miscellaneous Molecular Structure Pharmacology. Drug treatments Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - chemistry Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	A novel triarylimidazole derivative, SB-590885 ( 33), bearing a 2,3-dihydro-1 H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase. A novel triarylimidazole derivative, SB-590885 ( 33), bearing a 2,3-dihydro-1 H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.09.072