Preparation of Cyanoacrylate Nanoparticles Using Monosaccharides or Disaccharides

Preparation of Cyanoacrylate Nanoparticles Using Monosaccharides or Disaccharides

By using biomaterials, including monosaccharides and disaccharides, as polymeric stabilizing agents, the cyanoacrylate nanoparticles was prepared respectively, with particles diameter of approximately 200 nm or 300 nm. The new method was applied to load/encapsulate ampicillin (ABPC) and pDNA into na...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical & Pharmaceutical Bulletin 2008/01/01, Vol.56(1), pp.137-138
Hauptverfasser: Shirotake, Shoichi, Tomita, Yu'usuke, Yoshizaki, Shinji, Okuda, Kenji
Format: Artikel
Sprache:eng
Schlagworte:
Ampicillin - administration & dosage
cyanoacrylate
Cyanoacrylates - chemical synthesis
Disaccharides - chemistry
DNA - administration & dosage
Drug Carriers - chemistry
Drug Delivery Systems - methods
encapsulation
Microscopy, Electron, Scanning
Monosaccharides - chemistry
nanoparticle
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Particle Size
saccharide
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:By using biomaterials, including monosaccharides and disaccharides, as polymeric stabilizing agents, the cyanoacrylate nanoparticles was prepared respectively, with particles diameter of approximately 200 nm or 300 nm. The new method was applied to load/encapsulate ampicillin (ABPC) and pDNA into nanoparticles. Loading efficiency of ABPC was increased compared to the existing method in which dextran is used as a stabilizer. The pDNA encapusulation rate was 68.7%, by using glucose.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.56.137