Substituted indanylacetic acids as PPAR-α–γ activators
A series of substituted indanylacetic acids were prepared which showed a spectrum of agonist activity against PPAR nuclear receptor subtypes. A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2006-01, Vol.16 (2), p.297-301 |
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| creator | Lowe, Derek B. Bifulco, Neil Bullock, William H. Claus, Thomas Coish, Philip Dai, Miao Dela Cruz, Fernando E. Dickson, David Fan, Dongping Hoover-Litty, Helana Li, Tindy Ma, Xin Mannelly, Gretchen Monahan, Mary-Katherine Muegge, Ingo O’Connor, Stephen Rodriguez, Mareli Shelekhin, Tatiana Stolle, Andreas Sweet, Laurel Wang, Ming Wang, Yamin Zhang, Chengzhi Zhang, Hai-Jun Zhang, Mingbao Zhao, Kake Zhao, Qian Zhu, Jian Zhu, Lei Tsutsumi, Manami |
| description | A series of substituted indanylacetic acids were prepared which showed a spectrum of agonist activity against PPAR nuclear receptor subtypes.
A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes. |
| doi_str_mv | 10.1016/j.bmcl.2005.10.008 |
| format | Article |
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A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16275080</pmid><doi>10.1016/j.bmcl.2005.10.008</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.297-301 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetates - administration & dosage Acetates - chemical synthesis Acetates - pharmacology Administration, Oral Animals Biological and medical sciences Blood Glucose - drug effects Cholesterol, HDL - blood Cholesterol, HDL - drug effects Drug Evaluation, Preclinical General and cellular metabolism. Vitamins Ligands Medical sciences Mice Mice, Mutant Strains Mice, Obese Molecular Structure Oxazoles - chemistry Pharmacology. Drug treatments PPAR alpha - agonists PPAR alpha - metabolism PPAR gamma - agonists PPAR gamma - metabolism Structure-Activity Relationship Triglycerides - blood Triglycerides - metabolism |
| title | Substituted indanylacetic acids as PPAR-α–γ activators |
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