Substituted indanylacetic acids as PPAR-α–γ activators

A series of substituted indanylacetic acids were prepared which showed a spectrum of agonist activity against PPAR nuclear receptor subtypes. A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2006-01, Vol.16 (2), p.297-301
Hauptverfasser: Lowe, Derek B., Bifulco, Neil, Bullock, William H., Claus, Thomas, Coish, Philip, Dai, Miao, Dela Cruz, Fernando E., Dickson, David, Fan, Dongping, Hoover-Litty, Helana, Li, Tindy, Ma, Xin, Mannelly, Gretchen, Monahan, Mary-Katherine, Muegge, Ingo, O’Connor, Stephen, Rodriguez, Mareli, Shelekhin, Tatiana, Stolle, Andreas, Sweet, Laurel, Wang, Ming, Wang, Yamin, Zhang, Chengzhi, Zhang, Hai-Jun, Zhang, Mingbao, Zhao, Kake, Zhao, Qian, Zhu, Jian, Zhu, Lei, Tsutsumi, Manami
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Sprache:eng
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Zusammenfassung:A series of substituted indanylacetic acids were prepared which showed a spectrum of agonist activity against PPAR nuclear receptor subtypes. A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.10.008