Bone marrow microvessel density in chronic myeloproliferative disorders: a study of 115 patients with clinicopathological and molecular correlations

Summary Philadelphia‐negative chronic myeloproliferative disorders (CMD) include polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Angiogenesis is critical in the pathogenesis of PMF. We studied angiogenesis in 115 patients with CMD (23 PV, 24 ET, 46 PMF, 12 pos...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of haematology 2008-01, Vol.140 (2), p.162-168
Hauptverfasser:	Boveri, Emanuela, Passamonti, Francesco, Rumi, Elisa, Pietra, Daniela, Elena, Chiara, Arcaini, Luca, Pascutto, Cristiana, Castello, Alessandro, Cazzola, Mario, Magrini, Umberto, Lazzarino, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Anemia - etiology angiogenesis Biological and medical sciences Bone Marrow - blood supply Chronic Disease Female Hematologic and hematopoietic diseases Humans JAK2V617F Janus Kinase 2 - genetics L-Lactate Dehydrogenase - blood Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Mutation myelofibrosis Myeloproliferative Disorders - complications Myeloproliferative Disorders - genetics Myeloproliferative Disorders - pathology Neovascularization, Pathologic - pathology Platelet diseases and coagulopathies polycythemia Polycythemia Vera - genetics Polycythemia Vera - pathology Primary Myelofibrosis - genetics Primary Myelofibrosis - pathology thrombocythemia Thrombocythemia, Essential - genetics Thrombocythemia, Essential - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary Philadelphia‐negative chronic myeloproliferative disorders (CMD) include polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Angiogenesis is critical in the pathogenesis of PMF. We studied angiogenesis in 115 patients with CMD (23 PV, 24 ET, 46 PMF, 12 post‐PV and 10 post‐ET myelofibrosis) by assessment of microvessel density (MVD) in bone marrow (BM). Kruskall–Wallis analysis of variance showed that patients with PMF had significantly higher values of MVD than those with PV (P
ISSN:	0007-1048 1365-2141
DOI:	10.1111/j.1365-2141.2007.06885.x