Tramadol HCL has promise in on-demand use to treat premature ejaculation

Tramadol HCL has promise in on-demand use to treat premature ejaculation

Premature ejaculation (PE) is a worldwide problem without an approved treatment. Selective serotonin reuptake inhibitors (SSRIs) are widely used "off label" as pharmacotherapeutic agents in the treatment of PE. This study investigates Tramadol efficacy for on-demand treatment of PE. Intrav...

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Veröffentlicht in:Journal of sexual medicine 2008-01, Vol.5 (1), p.188-193
Hauptverfasser: Salem, Emad A, Wilson, Steven K, Bissada, Nabil K, Delk, John R, Hellstrom, Wayne J, Cleves, Mario A
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adult
Coitus
Cross-Over Studies
Drug Administration Schedule
Ejaculation - drug effects
Humans
Male
Middle Aged
Patient Satisfaction
Serotonin Agents - pharmacology
Serotonin Agents - therapeutic use
Sexual Dysfunction, Physiological - drug therapy
Single-Blind Method
Tramadol - pharmacology
Tramadol - therapeutic use
Treatment Outcome
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Zusammenfassung:Premature ejaculation (PE) is a worldwide problem without an approved treatment. Selective serotonin reuptake inhibitors (SSRIs) are widely used "off label" as pharmacotherapeutic agents in the treatment of PE. This study investigates Tramadol efficacy for on-demand treatment of PE. Intravaginal ejaculation latency time (IELT) was used as an objective tool to assess the efficacy of the investigated treatments. Single-blind, placebo-controlled, crossover, stopwatch monitored two-period study was conducted, on 60 patients with lifelong PE. PE was defined as IELT of
ISSN:1743-6095
1743-6109
DOI:10.1111/j.1743-6109.2006.00424.x