DNA Nanodevices

The molecular recognition properties of DNA molecules combined with the distinct mechanical properties of single and double strands of DNA can be utilized for the construction of nanodevices, which can perform ever more tasks with possible applications ranging from nanoconstruction to intelligent drug delivery. With the help of DNA it is possible to construct machinelike devices that are capable of rotational motion, pulling and stretching, or even unidirectional motion. It is possible to devise autonomous nanodevices, to grab and release molecules, and also to perform simple information‐processing tasks. The mechanical and molecular‐recognition properties of DNA molecules can be used to construct artificial molecular machines and devices. This Review describes the latest developments in the field of DNA nanodevices. DNA can be utilized to build molecular motors, continuously running devices, or even machines that can grab and release molecules. Methods to couple device action with molecular information processing are also discussed.