Signal Transmission from Individual Mammalian Nerve Cell to Field-Effect Transistor

Direct electrical interfacing of a semiconductor device to an individual mammalian nerve cell is reported. The firing neuron directly controls the source–drain current of a buried channel electrolyte–oxide–silicon (EOS) field‐effect transistor. The experiment demonstrates the feasibility of noninvasive monitoring of neuronal systems by semiconductor chips at the level of individual cells and lays the foundation for applications of very‐large‐scale integration technology in neuroscience and pharmacology.